3-FLUORO-4-IODOBENZONITRILE

Base Information

• Chemical Name: 3-FLUORO-4-IODOBENZONITRILE
• CAS No.: 887266-99-1
• Molecular Formula: C7H3FIN
• Molecular Weight: 247.01
• Hs Code.: 29269090
• Mol file: 887266-99-1.mol

Synonyms:4-Cyano-2-fluoroiodobenzene;5-Fluoro-4-iodobenzonitrile;3-FLUORO-4-IODOBENZONITRILE3

Chemical Property of 3-FLUORO-4-IODOBENZONITRILE

Chemical Property:

• Melting Point: 110-113°C
• Boiling Point: 268.1 °C at 760 mmHg
• Flash Point: 115.9 °C
• Density: 1.98 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive

Purity/Quality:

97% ^*data from raw suppliers

3-Fluoro-4-iodobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-4-IODOBENZONITRILE

There total 3 articles about 3-FLUORO-4-IODOBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyano-2-fluoroaniline (63069-50-1) → 3-fluoro-4-iodo-benzonitrile (887266-99-1)

Guidance literature:

4-cyano-2-fluoroaniline; With toluene-4-sulfonic acid; In acetonitrile; at 22 - 26 ℃; for 4h;

With potassium iodide; sodium nitrite; In water; acetonitrile; at 0 ℃; for 1h;

Reference yield:

3-fluoro-4-nitrobenzonitrile (218632-01-0) → 3-fluoro-4-iodo-benzonitrile (887266-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iron; hydrogenchloride; water / methanol / 2 h / 22 - 26 °C

2.1: toluene-4-sulfonic acid / acetonitrile / 4 h / 22 - 26 °C

2.2: 1 h / 0 °C

With hydrogenchloride; water; iron; toluene-4-sulfonic acid; In methanol; acetonitrile;

Reference yield:

→ 3-fluoro-4-iodo-benzonitrile (887266-99-1)

Guidance literature:

With toluene-4-sulfonic acid; In acetonitrile; at 20 ℃; for 4h;

With potassium iodide; sodium nitrite; In water; acetonitrile; at 0 ℃; for 1h;

upstream raw materials:

4-cyano-2-fluoroaniline

3-fluoro-4-nitrobenzonitrile

Downstream raw materials:

(4-cyano-2-fluorophenyl)boronic acid

Refernces

• 1、 -. "IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS". Page/Page column 75; 80. . Retrieved 2016/04/20.