S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

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Chemical Name:S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate
CAS No.:1247052-85-2
Molecular Formula:C₃₀H₄₁ClN₄O₆S₂
Molecular Weight:653.264
Hs Code.:

S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

Synonyms:S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

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Chemical Property of S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

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Technology Process of S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

There total 6 articles about S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1247052-65-8
(-)-(3S,9S,14aR)-9-benzyl-3-(but-3-enyl)-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone

: 791096-00-9
dithiocarbonic acid (3-chloro-2-oxo-propyl) ester ethyl ester

: 1247052-85-2
S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

Guidance literature:: With dilauryl peroxide; In 1,2-dichloro-ethane; Reflux; Inert atmosphere;

Reference yield:

: 1247052-63-6
C₃₃H₅₀N₄O₇

: 1247052-85-2
S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

Guidance literature:: Multi-step reaction with 3 steps

1: 3 h / 0 °C

2: triethylamine; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3: dilauryl peroxide / 1,2-dichloro-ethane / Reflux; Inert atmosphere

With dilauryl peroxide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 92136-57-7
(S)-2-tert-butoxycarbonylamino-hex-5-enoic acid methyl ester

: 1247052-85-2
S-{1-[(3S,9S,14aR)-9-benzyl-6,6-dimethyl-1,4,7,10-tetraoxotetradecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecin-3-yl]-7-chloro-6-oxoheptan-3-yl} O-ethyl carbonodithioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

1.2: pH 3

2.1: triethylamine; dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3.1: 3 h / 0 °C

4.1: triethylamine; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5.1: dilauryl peroxide / 1,2-dichloro-ethane / Reflux; Inert atmosphere

With dilauryl peroxide; water; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; HATU; lithium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide;