N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

Base Information

Chemical Name:N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide
CAS No.:1198802-86-6
Molecular Formula:C₁₉H₁₆ClN₅O₄S₂
Molecular Weight:477.952
Hs Code.:

Synonyms:N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

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Chemical Property of N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

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Technology Process of N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

There total 5 articles about N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1010120-58-7
N-(5-bromo-2-chloro-pyridine-3-yl)methanesulfonamide

: 1198437-73-8
1-((4-phenyl)sulfonyl)-6-(trimethylstannyl)-1H-indazol-4-amine

: 1198802-86-6
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 0.833333h; Product distribution / selectivity; microwave vial;

Reference yield:

: 885518-50-3
6-bromo-1H-indazole-4-amine

: 1198802-86-6
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

1.2: 0.25 h / 20 °C

1.3: 20 °C

2.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 120 °C / microwave irradiation

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.83 h / 120 °C / microwave vial

With sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1198437-71-6
6-bromo-1-(phenylsulfonyl)-1H-indazol-4-amine

: 1198802-86-6
N-{5-[4-amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 120 °C / microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.83 h / 120 °C / microwave vial

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene;