Tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate
CAS No.:886768-17-8
Molecular Formula:C16H24 N2 O3
Molecular Weight:292.37
Hs Code.:2933599090
European Community (EC) Number:832-297-5
DSSTox Substance ID:DTXSID70587676
Mol file:886768-17-8.mol

Synonyms:886768-17-8;TERT-BUTYL 3-(4-METHOXYPHENYL)PIPERAZINE-1-CARBOXYLATE;1-BOC-3-(4-METHOXYPHENYL)PIPERAZINE;3-(4-METHOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;MFCD06660434;SCHEMBL12520694;DTXSID70587676;CFWSKJOGTKJXPT-UHFFFAOYSA-N;1228557-08-1;1228561-01-0;AKOS005257318;AB26731;AB46461;AB46465;MCULE-3440037019;AS-35474;DA-01524;CS-0126886;EN300-374308;A915017;Z2785965913;3-(4-Methoxyphenyl)-piperazine-1-carboxylic acid tert-butyl ester;(R)-3-(4-METHOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-(4-METHOXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Suppliers and Price of Tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Boc-3-(4-Methoxyphenyl)piperazine 95+%
1g
$ 507.00

Chemenu
tert-Butyl3-(4-methoxyphenyl)piperazine-1-carboxylate 95%+
1g
$ 689.00

American Custom Chemicals Corporation
TERT-BUTYL-3-(4-METHOXYPHENYL)PIPERAZINE-1-CARBOXYLATE 95.00%
5MG
$ 452.09

Alichem
1-Boc-3-(4-Methoxyphenyl)piperazine
5g
$ 1360.68

Alichem
1-Boc-3-(4-Methoxyphenyl)piperazine
250mg
$ 150.48

Alichem
1-Boc-3-(4-Methoxyphenyl)piperazine
1g
$ 451.26

AK Scientific
tert-Butyl3-(4-methoxyphenyl)piperazine-1-carboxylate
250mg
$ 280.00

Total 9 raw suppliers

Chemical Property of Tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

Chemical Property:

Vapor Pressure:7.65E-07mmHg at 25°C
Refractive Index:1.516
Boiling Point:407.3°C at 760 mmHg
Flash Point:200.1°C
PSA：50.80000
Density:1.087g/cm³
LogP:2.84330
Storage Temp.:2-8°C
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:292.17869263
Heavy Atom Count:21
Complexity:346

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-3-(4-Methoxyphenyl)piperazine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCNC(C1)C2=CC=C(C=C2)OC

Technology Process of Tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

There total 11 articles about Tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₄₈N₂O₃Sn

: 886768-17-8
tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol500210z

Reference yield:

: 1557287-99-6
tert-butyl (2-aminoethyl)((tributylstannyl)methyl)carbamate

: 123-11-5
4-methoxy-benzaldehyde

: 886768-17-8
tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

2: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane;
DOI:10.1021/ol500210z

Reference yield:

: 77361-32-1
N-(2-tert-butoxycarbonylaminoethyl)phthalimide

: 886768-17-8
tert-butyl 3-(4-methoxyphenyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

1.2: 6 h / 0 - 20 °C

2.1: hydrazine / ethanol / 0.33 h / Reflux

3.1: dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

4.1: 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 12 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); sodium hydride; hydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol500210z