2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide

Base Information

• Chemical Name: 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide
• CAS No.: 153906-10-6
• Molecular Formula: C₁₆H₂₁Cl₂N₃O₂
• Molecular Weight: 358.268
• Mol file: 153906-10-6.mol

Synonyms:2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide

Chemical Property of 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide

There total 3 articles about 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-(2-aminoethyl)pyrrolidine (7154-73-6) + N-(3,4-dichlorophenylacetyl)glycine (153906-08-2) → 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide (153906-10-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00028a016

Reference yield:

3,4-dichlorophenyl acetic acid (5807-30-7) → 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide (153906-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / 1-((dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, Et₃N / CH₂Cl₂ / Ambient temperature

2: 95 percent / 10percent KOH/MeOH / Ambient temperature

3: 81 percent / DCC / CH₂Cl₂ / Ambient temperature

With methanol; potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00028a016

Reference yield:

[2-(3,4-Dichloro-phenyl)-acetylamino]-acetic acid methyl ester (153906-07-1) → 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide (153906-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 10percent KOH/MeOH / Ambient temperature

2: 81 percent / DCC / CH₂Cl₂ / Ambient temperature

With methanol; potassium hydroxide; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00028a016

upstream raw materials:

1-(2-aminoethyl)pyrrolidine

N-(3,4-dichlorophenylacetyl)glycine

3,4-dichlorophenyl acetic acid

[2-(3,4-Dichloro-phenyl)-acetylamino]-acetic acid methyl ester