Glycine, N-[(3,4-dichlorophenyl)acetyl]-

Base Information

• Chemical Name: Glycine, N-[(3,4-dichlorophenyl)acetyl]-
• CAS No.: 153906-08-2
• Molecular Formula: C10H9Cl2NO3
• Molecular Weight: 262.092
• DSSTox Substance ID: DTXSID10440433
• Wikidata: Q82256740
• Mol file: 153906-08-2.mol

Synonyms:Glycine, N-[(3,4-dichlorophenyl)acetyl]-;153906-08-2;DTXSID10440433;AKOS008984231

Chemical Property of Glycine, N-[(3,4-dichlorophenyl)acetyl]-

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 260.9959485
• Heavy Atom Count: 16
• Complexity: 273

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CC(=O)NCC(=O)O)Cl)Cl

Technology Process of Glycine, N-[(3,4-dichlorophenyl)acetyl]-

There total 2 articles about Glycine, N-[(3,4-dichlorophenyl)acetyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[2-(3,4-Dichloro-phenyl)-acetylamino]-acetic acid methyl ester (153906-07-1) → N-(3,4-dichlorophenylacetyl)glycine (153906-08-2)

Guidance literature:

With methanol; potassium hydroxide; Ambient temperature;

DOI:10.1021/jm00028a016

Reference yield:

3,4-dichlorophenyl acetic acid (5807-30-7) → N-(3,4-dichlorophenylacetyl)glycine (153906-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / 1-((dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, Et₃N / CH₂Cl₂ / Ambient temperature

2: 95 percent / 10percent KOH/MeOH / Ambient temperature

With methanol; potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00028a016

Reference yield: 81.0%

1-(2-aminoethyl)pyrrolidine (7154-73-6) + N-(3,4-dichlorophenylacetyl)glycine (153906-08-2) → 2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide (153906-10-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00028a016

upstream raw materials:

[2-(3,4-Dichloro-phenyl)-acetylamino]-acetic acid methyl ester

3,4-dichlorophenyl acetic acid

Downstream raw materials:

2-(3,4-Dichloro-phenyl)-N-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-acetamide

N-[(Carbamoylmethyl-carbamoyl)-methyl]-2-(3,4-dichloro-phenyl)-acetamide

(Z)-2-(3,4-dichlorobenzyl)-4-(3,4-dimethoxybenzylidene)-5(4H)-oxazolone

(Z)-2-(3,4-dichlorophenylacetylamino)-3-(3,4-dimethoxyphenyl)-N-methyl-2-propenamide

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