Technology Process of 10-Deoxybaccatin 7-xanthate
There total 6 articles about 10-Deoxybaccatin 7-xanthate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / n-BuLi / tetrahydrofuran; hexane / 1.) -40 deg c, 40 min, 2.) -20 deg C, 90 min
2: 99 percent / AlBN, Bu3SnH / toluene / 1 h / 90 °C
3: 76 percent / conc. HCl / acetonitrile / 0.5 h / -10 °C
4: 1.) NaH / 1.) THF, r.t., 2 h, 2.) overnight
With
hydrogenchloride; n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride;
In
tetrahydrofuran; hexane; toluene; acetonitrile;
DOI:10.1021/jo00085a040
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 76 percent / conc. HCl / acetonitrile / 0.5 h / -10 °C
2: 1.) NaH / 1.) THF, r.t., 2 h, 2.) overnight
With
hydrogenchloride; sodium hydride;
In
acetonitrile;
DOI:10.1021/jo00085a040
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / AlBN, Bu3SnH / toluene / 1 h / 90 °C
2: 76 percent / conc. HCl / acetonitrile / 0.5 h / -10 °C
3: 1.) NaH / 1.) THF, r.t., 2 h, 2.) overnight
With
hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride;
In
toluene; acetonitrile;
DOI:10.1021/jo00085a040
