4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

Base Information

Chemical Name:4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione
CAS No.:118966-44-2
Molecular Formula:C₂₄H₂₈O₄
Molecular Weight:380.484
Hs Code.:

Synonyms:4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

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Chemical Property of 4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

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Technology Process of 4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

There total 3 articles about 4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 139484-11-0
3-hydroxy-2-[(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)(4-methylphenyl)methyl]-5,5-dimethylcyclohex-2-en-1-one

: 118966-45-3
4’,4’,6,6-tetramethyl-3-(p-tolyl)-6,7-dihydro-3H-spiro[benzofuran-2,1’-cyclohexane]-2’,4,6’(5H)-trione

: 118966-44-2
4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

Guidance literature:: With manganese(III) triacetate dihydrate; In acetic acid; for 0.0333333h; Reflux;
DOI:10.1016/j.tet.2020.131165

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 105071-90-7
triphenylbismuthonio-4,4-dimethyl-2,6-dioxocyclohexane-1-ide

: 603-33-8
triphenylbismuthane

: 118966-45-3
4’,4’,6,6-tetramethyl-3-(p-tolyl)-6,7-dihydro-3H-spiro[benzofuran-2,1’-cyclohexane]-2’,4,6’(5H)-trione

: 118966-44-2
4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

Guidance literature:: In benzene; at 70 ℃; for 12h; Yield given. Yields of byproduct given;
DOI:10.1246/cl.1988.849

Reference yield:

: 126-81-8
dimedone

: 118966-45-3
4’,4’,6,6-tetramethyl-3-(p-tolyl)-6,7-dihydro-3H-spiro[benzofuran-2,1’-cyclohexane]-2’,4,6’(5H)-trione

: 118966-44-2
4',4',6,6-tetramethyl-2-(p-tolyl)-6,7-dihydro-2H-spiro[benzofuran-3,1'-cyclohexane]-2',4,6'(5H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / ethanol; water / 20 °C

2: manganese(III) triacetate dihydrate / acetic acid / 0.03 h / Reflux

With piperidine; manganese(III) triacetate dihydrate; In ethanol; water; acetic acid;
DOI:10.1016/j.tet.2020.131165