C₄₉H₄₄F₃N₃O₂₀

Base Information

• Chemical Name: C₄₉H₄₄F₃N₃O₂₀
• CAS No.: 179992-21-3
• Molecular Formula: C₄₉H₄₄F₃N₃O₂₀
• Molecular Weight: 1051.89
• Mol file: 179992-21-3.mol

Synonyms:C₄₉H₄₄F₃N₃O₂₀

Chemical Property of C₄₉H₄₄F₃N₃O₂₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₄₄F₃N₃O₂₀

There total 10 articles about C₄₉H₄₄F₃N₃O₂₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

(+)-Daunomycinone (21794-55-8) + p-Nitrobenzoyl 3-O-p-nitrobenzoyl-4-O-(3-N-trifluoroacetyl-4-O-p-nitrobenzoyl-α-L-daunosaminyl)-2-deoxy-L-rhamnoside (180182-56-3) → C49H44F3N3O20 (179992-21-3)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In diethyl ether; dichloromethane; at -20 ℃; for 1h;

DOI:10.1039/P19960001327

Reference yield:

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose (52583-22-9) → C49H44F3N3O20 (179992-21-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 79 percent / TMSOTf / CH₂Cl₂ / 0.67 h / -15 °C

2: 90 percent / Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O / 1 h / Ambient temperature

3: pyridine / CH₂Cl₂ / 2 h / 0 °C

4: 57 percent / CF₃SO₃SiMe₃ / CH₂Cl₂; diethyl ether / 1 h / -20 °C

With pyridine; ammonium cerium(IV) nitrate; trimethylsilyl trifluoromethanesulfonate; In diethyl ether; dichloromethane; water; acetonitrile;

DOI:10.1039/P19960001327

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → C49H44F3N3O20 (179992-21-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) Bu₂SnO, 2.) Et₃N / 1.) toluene, reflux, 6 h, 2.) toluene, -40 deg C, 2 h

2: 79 percent / TMSOTf / CH₂Cl₂ / 0.67 h / -15 °C

3: 90 percent / Ce(NH₄)2(NO₃)6 / acetonitrile; H₂O / 1 h / Ambient temperature

4: pyridine / CH₂Cl₂ / 2 h / 0 °C

5: 57 percent / CF₃SO₃SiMe₃ / CH₂Cl₂; diethyl ether / 1 h / -20 °C

With pyridine; ammonium cerium(IV) nitrate; trimethylsilyl trifluoromethanesulfonate; di(n-butyl)tin oxide; triethylamine; In diethyl ether; dichloromethane; water; acetonitrile;

DOI:10.1039/P19960001327

upstream raw materials:

(+)-Daunomycinone

p-Nitrobenzoyl 3-O-p-nitrobenzoyl-4-O-(3-N-trifluoroacetyl-4-O-p-nitrobenzoyl-α-L-daunosaminyl)-2-deoxy-L-rhamnoside

2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose

4-nitro-benzoyl chloride