tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate
CAS No.:1422970-01-1
Molecular Formula:C₁₉H₂₉BrN₂O₆S
Molecular Weight:493.419
Hs Code.:

Synonyms:tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

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Chemical Property of tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

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Technology Process of tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

There total 1 articles about tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 89599-01-9
3-bromobenzenesulfonamide

: 13734-40-2
(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid

: 1422970-01-1
tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

Guidance literature:: (2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

3-bromobenzenesulfonamide; With 1-hydroxy-7-aza-benzotriazole; In dichloromethane; for 2h;
DOI:10.1021/jm301756m

Reference yield: 54.3%

: 1422970-01-1
tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

: 74-88-4
methyl iodide

: 1422970-13-5
tert-butyl ((2S,3R)-1-(3-bromo-N-methylbenzenesulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

Guidance literature:: With caesium carbonate; In water; N,N-dimethyl-formamide; at 65 ℃; for 12h; Inert atmosphere; Sonication;
DOI:10.1021/jm301756m

Reference yield:

: 1245816-25-4
(3-methyl-1H-indazol-5-yl)boronic acid

: 1422970-01-1
tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate

: (2S,3R)-2-amino-3-hydroxy-N-((3-(3-methyl-1H-indazol-5-yl)phenyl)sulfonyl)butanamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; at 140 ℃; Inert atmosphere; Microwave irradiation;
DOI:10.1021/jm301756m