2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester

Base Information

• Chemical Name: 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester
• CAS No.: 210988-78-6
• Molecular Formula: C₅₂H₅₃N₇O₆
• Molecular Weight: 872.036
• Mol file: 210988-78-6.mol

Synonyms:2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester

Chemical Property of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester

There total 11 articles about 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-Dimethylacryloyl chloride (3350-78-5) → 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester (210988-78-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 72 percent / pyridine / 1.5 h

2: 71 percent / NaH / dimethylformamide / Ambient temperature

3: 91 percent / AcOH / ethanol / 3 h / Heating

4: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

5: 86 percent / Et₃N / dimethylformamide

6: 1.) 0.1N ethanolic KOH / 2.) acetone, RT, overnight

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.973

Reference yield:

1-Chloroethyl ethyl carbonate (50893-36-2) → 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester (210988-78-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetonitrile / 0.75 h / 60 - 70 °C

2: 1.) 0.1N ethanolic KOH / 2.) acetone, RT, overnight

With potassium hydroxide; sodium iodide; In acetonitrile;

DOI:10.1248/cpb.46.973

Reference yield:

ethyl N-cyanovalerimidate → 2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester (210988-78-6)

Guidance literature:

Multi-step reaction with 9 steps

1: Et₃N / ethanol / Ambient temperature

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, RT, 2 h

3: NaH / dimethylformamide / 3 h / Ambient temperature

4: 72 percent / pyridine / 1.5 h

5: 71 percent / NaH / dimethylformamide / Ambient temperature

6: 91 percent / AcOH / ethanol / 3 h / Heating

7: 73 percent / 1N aq. NaOH / ethanol / Ambient temperature

8: 86 percent / Et₃N / dimethylformamide

9: 1.) 0.1N ethanolic KOH / 2.) acetone, RT, overnight

With pyridine; potassium hydroxide; sodium hydroxide; sodium hydride; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.973

upstream raw materials:

2-Butyl-5-[methyl-(3-methyl-but-2-enoyl)-amino]-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid

ethyl 1-iodoethylcarbonate

3,3-Dimethylacryloyl chloride

1-Chloroethyl ethyl carbonate