Technology Process of 3-(benzyloxy)-10-hydroxy-7,8,9,10-tetrahydrophenanthridine
There total 11 articles about 3-(benzyloxy)-10-hydroxy-7,8,9,10-tetrahydrophenanthridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 25 ℃;
for 2h;
DOI:10.1021/ja00049a023
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / DCC, DMAP / CH2Cl2 / 14 h / Ambient temperature
2: 87 percent / tetrahydrofuran / 96 h / Heating
3: 1.) NaH, 2.) tetra-n-butylammonium iodide / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 1 h
4: 1.) 37percent aq. HCl, 2.) DIBAL, LiAlH4, 3.) silica gel, O2
5: 88 percent / m-CPBA / CH2Cl2 / 0.5 h / 25 °C
6: 80 percent / 14 h / 25 °C
7: 98 percent / K2CO3 / methanol / 2 h / 25 °C
With
hydrogenchloride; dmap; lithium aluminium tetrahydride; oxygen; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00049a023
- Guidance literature:
-
Multi-step reaction with 8 steps
1: aq. NaOH / methanol / 15 h / Heating
2: 96 percent / DCC, DMAP / CH2Cl2 / 14 h / Ambient temperature
3: 87 percent / tetrahydrofuran / 96 h / Heating
4: 1.) NaH, 2.) tetra-n-butylammonium iodide / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 1 h
5: 1.) 37percent aq. HCl, 2.) DIBAL, LiAlH4, 3.) silica gel, O2
6: 88 percent / m-CPBA / CH2Cl2 / 0.5 h / 25 °C
7: 80 percent / 14 h / 25 °C
8: 98 percent / K2CO3 / methanol / 2 h / 25 °C
With
hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; oxygen; silica gel; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja00049a023
