4-Hydroxy-4-(trifluoromethyl)cyclohexan-1-one

Base Information

Chemical Name:4-Hydroxy-4-(trifluoromethyl)cyclohexan-1-one
CAS No.:120929-90-0
Molecular Formula:C₇H₉F₃O₂
Molecular Weight:182.142
Hs Code.:
European Community (EC) Number:866-144-9

Synonyms:4-hydroxy-4-(trifluoromethyl)cyclohexan-1-one;120929-90-0;4-hydroxy-4-(trifluoromethyl)cyclohexanone;MFCD18917407;SCHEMBL1372643;AKOS013584429;PB39887;4-Hvdroxy-4-trifluoromethylcyclohexanone;4-Hydroxy-4-trifluoromethylcyclohexanone;AS-78991;SY186431;DB-184923;CS-0185234;EN300-79129;D79027;Z1209979802

Suppliers and Price of 4-Hydroxy-4-(trifluoromethyl)cyclohexan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 4-Hydroxy-4-(trifluoromethyl)cyclohexan-1-one

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:182.05546401
Heavy Atom Count:12
Complexity:187

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(CCC1=O)(C(F)(F)F)O

Technology Process of 4-Hydroxy-4-(trifluoromethyl)cyclohexan-1-one

There total 4 articles about 4-Hydroxy-4-(trifluoromethyl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1248081-37-9
4-hydroxy-4-(trifluoromethyl)cyclohexanone ethylene ketal

: 120929-90-0
4-hydroxy-4-(trifluoromethyl)cyclohexan-1-one

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 55.0%

: 4746-97-8
cyclohexanedione monoethylene ketal

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 120929-90-0
4-hydroxy-4-(trifluoromethyl)cyclohexan-1-one

Guidance literature:: cyclohexanedione monoethylene ketal; (trifluoromethyl)trimethylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;
DOI:10.1039/c5ob01924a

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 120929-90-0
4-hydroxy-4-(trifluoromethyl)cyclohexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C

2: hydrogenchloride; water / tetrahydrofuran / 24 h / 20 °C

With hydrogenchloride; tetrabutyl ammonium fluoride; water; In tetrahydrofuran;