1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine

Base Information

• Chemical Name: 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine
• CAS No.: 226068-69-5
• Molecular Formula: C₂₀H₃₀ClN₃O₃
• Molecular Weight: 395.93
• Mol file: 226068-69-5.mol

Synonyms:1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine

Chemical Property of 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine

There total 8 articles about 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine (226068-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 48 h / Ambient temperature

2: H₂ / 10 percent Pd/C / ethanol / 12 h / Ambient temperature

3: 1.) Al(CH₃)2 / 1.) toluene, 1 h, 2.) toluene, a) reflux, 4 h, b) RT, overnight

With Al(CH₃)2; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm981099b

Reference yield:

N,N-dibenzyl-2-(tetrahydro-2H-pyran-2-yloxy)ethanamine (1026253-80-4) → 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine (226068-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / ethanol / 12 h / Ambient temperature

2: 1.) Al(CH₃)2 / 1.) toluene, 1 h, 2.) toluene, a) reflux, 4 h, b) RT, overnight

With Al(CH₃)2; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm981099b

Reference yield:

ethyl 2-piperazinecarboxylate (89941-07-1) → 1-(2'-chlorobenzyl)-4-methyl-2-<((tetrahydropyran-2-yloxy)ethylamino)carbonyl>piperazine (226068-69-5)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / -10 °C

2: K₂CO₃, KI / acetonitrile / 15 h / 80 °C

3: aq. HCl / acetone / 3 h / Ambient temperature

4: HCO₂H / methanol / 20 h / Heating

5: 1.) Al(CH₃)2 / 1.) toluene, 1 h, 2.) toluene, a) reflux, 4 h, b) RT, overnight

With hydrogenchloride; formic acid; Al(CH₃)2; potassium carbonate; triethylamine; potassium iodide; In methanol; dichloromethane; acetone; acetonitrile;

DOI:10.1021/jm981099b

upstream raw materials:

2-[(tetrahydropyran-2-yl)oxy]ethylamine

ethyl 1-(2'-chlorobenzyl)-4-methylpiperazine-2-carboxylate

3,4-dihydro-2H-pyran

ethyl 2-piperazinecarboxylate

Downstream raw materials:

1-(2'-chlorobenzyl)-4-methyl-2-<(hydroxyethylamino)carbonyl>piperazine

1-(2'-chlorobenzyl)-4-methyl-2-<(chloroethylamino)carbonyl>piperazine