5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester

Base Information

• Chemical Name: 5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester
• CAS No.: 741721-52-8
• Molecular Formula: C₁₂H₉F₂NO₄
• Molecular Weight: 269.205
• Mol file: 741721-52-8.mol

Synonyms:5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester

Chemical Property of 5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester

There total 2 articles about 5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl pent-4-ynoate (21565-82-2) → 5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester (741721-52-8)

Guidance literature:

With palladium diacetate; copper(l) iodide; triphenylphosphine; diethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.07.064

Reference yield:

4-pentynoic acid (6089-09-4) → 5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester (741721-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / sulfuric acid

2: Pd(OAc)2; PPh₃; CuI / HNEt₂ / dimethylformamide

With palladium diacetate; copper(l) iodide; sulfuric acid; triphenylphosphine; diethylamine; In N,N-dimethyl-formamide; 2: Sonagashira coupling;

DOI:10.1016/j.bmcl.2006.07.064

Reference yield: 91.0%

5-(2,5-difluoro-3-nitro-phenyl)-pent-4-ynoic acid methyl ester (741721-52-8) → 5-(3-amino-2,5-difluoro-phenyl)-pentanoic acid methyl ester (741721-53-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 20h; under 2327.23 Torr;

upstream raw materials:

methyl pent-4-ynoate

4-pentynoic acid

Downstream raw materials:

5-(3-amino-2,5-difluoro-phenyl)-pentanoic acid methyl ester

5-(3-ethoxycarbonylamino-2,5-difluoro-phenyl)-pentanoic acid

5-(3-ethoxycarbonylamino-2,5-difluoro-phenyl)-pentanoic acid methyl ester