2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

Base Information

Chemical Name:2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole
CAS No.:129366-61-6
Molecular Formula:C₁₁H₈Cl₂F₃N₃S
Molecular Weight:342.172
Hs Code.:

Synonyms:2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

Chemical Property:

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Technology Process of 2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

There total 8 articles about 2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 129366-50-3
[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

: 5188-07-8
sodium thiomethoxide

: 129366-61-6
2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

Guidance literature:: In acetonitrile; at 20 ℃; for 72h;
DOI:10.1002/(SICI)1096-9063(199610)48:2<189::AID-PS461>3.0.CO;2-#

Reference yield:

: 147770-44-3
3-(methylthio)pyruvaldehyde-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazone

: 129366-61-6
2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

Guidance literature:: With hydroxylamine-O-sulfonic acid; In water; acetonitrile;

Reference yield:

: 86398-94-9
2,6-dichloro-4-(trifluoromethyl)phenyl hydrazine

: 129366-61-6
2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-4-(methylthiomethyl)-2H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / 2 h / Heating

2: 95 percent / AcOH / 0.75 h / 20 °C

3: 82 percent / Cs₂CO₃ / tetrahydrofuran / 1 h / 20 °C

4: 86 percent / 1,3,5-trioxane; 2 M aq. HCl / 6 h / Heating

5: 92 percent / NaBH₄ / propan-2-ol; methanol / 20 °C

6: 80 percent / Et₃N / tetrahydrofuran / 0.67 h / 20 °C

7: 56 percent / acetonitrile / 72 h / 20 °C

With 1,3,5-Trioxan; hydrogenchloride; sodium tetrahydroborate; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; isopropyl alcohol; acetonitrile; 1: Condensation / 2: Acetylation / 3: Cyclization / 4: Hydrolysis / 5: Reduction / 6: Esterification / 7: Substitution;
DOI:10.1002/(SICI)1096-9063(199610)48:2<189::AID-PS461>3.0.CO;2-#