[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

Base Information

Chemical Name:[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate
CAS No.:129366-50-3
Molecular Formula:C₁₁H₈Cl₂F₃N₃O₃S
Molecular Weight:390.17
Hs Code.:

Synonyms:[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

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Technology Process of [2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

There total 6 articles about [2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 124-63-0
methanesulfonyl chloride

: 129366-49-0
[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methanol

: 129366-50-3
[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.666667h;
DOI:10.1002/(SICI)1096-9063(199610)48:2<189::AID-PS461>3.0.CO;2-#

Reference yield:

: 86398-94-9
2,6-dichloro-4-(trifluoromethyl)phenyl hydrazine

: 129366-50-3
[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / 2 h / Heating

2: 95 percent / AcOH / 0.75 h / 20 °C

3: 82 percent / Cs₂CO₃ / tetrahydrofuran / 1 h / 20 °C

4: 86 percent / 1,3,5-trioxane; 2 M aq. HCl / 6 h / Heating

5: 92 percent / NaBH₄ / propan-2-ol; methanol / 20 °C

6: 80 percent / Et₃N / tetrahydrofuran / 0.67 h / 20 °C

With 1,3,5-Trioxan; hydrogenchloride; sodium tetrahydroborate; caesium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; isopropyl alcohol; 1: Condensation / 2: Acetylation / 3: Cyclization / 4: Hydrolysis / 5: Reduction / 6: Esterification;
DOI:10.1002/(SICI)1096-9063(199610)48:2<189::AID-PS461>3.0.CO;2-#

Reference yield:

: 129366-62-7
2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazole-4-carbaldehyde

: 129366-50-3
[2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaBH₄ / propan-2-ol; methanol / 20 °C

2: 80 percent / Et₃N / tetrahydrofuran / 0.67 h / 20 °C

With sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; isopropyl alcohol; 1: Reduction / 2: Esterification;
DOI:10.1002/(SICI)1096-9063(199610)48:2<189::AID-PS461>3.0.CO;2-#