N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide

Base Information

• Chemical Name: N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide
• CAS No.: 1430234-32-4
• Molecular Formula: C₂₁H₂₇F₃N₂O₂
• Molecular Weight: 396.453
• Mol file: 1430234-32-4.mol

Synonyms:N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide

Chemical Property of N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide

There total 2 articles about N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-Trifluoromethylbenzaldehyde (455-19-6) + dicyclohexyl-carbodiimide (538-75-0) → N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide (1430234-32-4)

Guidance literature:

With potassium carbonate; 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazolium chloride; In acetonitrile; at 25 ℃; for 18h;

DOI:10.1021/ol400672c

Reference yield: 80.0%

2-(4-Fluorophenyl)-2-(N-methyl-4-(trifluoromethyl) benzamido)acetic acid + dicyclohexyl-carbodiimide (538-75-0) → N-cyclohexyl-N-(cyclohexylcarbamoyl)-4-(trifluoromethyl)benzamide (1430234-32-4)

Guidance literature:

2-(4-Fluorophenyl)-2-(N-methyl-4-(trifluoromethyl) benzamido)acetic acid; dicyclohexyl-carbodiimide; In acetonitrile; at 55 ℃; for 0.5h;

With diisopropylamine; In acetonitrile; at 90 ℃;

DOI:10.1080/00397911.2018.1489966

upstream raw materials:

4-Trifluoromethylbenzaldehyde

dicyclohexyl-carbodiimide