2-(2-Hydroxyphenyl)acetohydrazide

Base Information

• Chemical Name: 2-(2-Hydroxyphenyl)acetohydrazide
• CAS No.: 22446-43-1
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• European Community (EC) Number: 664-892-9
• DSSTox Substance ID: DTXSID501286525
• Nikkaji Number: J620.554B
• Mol file: 22446-43-1.mol

Synonyms:2-(2-hydroxyphenyl)acetohydrazide;22446-43-1;SCHEMBL5738109;DTXSID501286525;2-Hydroxybenzeneacetic acid hydrazide;AKOS006337697;(2-Hydroxyphenyl)acetic acid hydrazide;EN300-301082

Chemical Property of 2-(2-Hydroxyphenyl)acetohydrazide

Chemical Property:

• XLogP3: -0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 161

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CC(=O)NN)O

Technology Process of 2-(2-Hydroxyphenyl)acetohydrazide

There total 6 articles about 2-(2-Hydroxyphenyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

coumarandione (4732-72-3) → (2-hydroxy-phenyl)-acetic acid hydrazide (22446-43-1)

Guidance literature:

With hydrazine hydrate; for 0.25h; Heating;

DOI:10.1080/00397919408010603

Reference yield:

ethyl 2-(2-hydroxyphenyl)acetate (41873-65-8) → (2-hydroxy-phenyl)-acetic acid hydrazide (22446-43-1)

Guidance literature:

With hydrazine hydrate; at 80 ℃;

DOI:10.1016/j.tetlet.2015.01.077

Reference yield:

→ (2-hydroxy-phenyl)-acetic acid hydrazide (22446-43-1)

Guidance literature:

With hydrazine hydrate;

upstream raw materials:

coumarandione

benzofuran-2(3H)-one

ethanol

hydrazine hydrate

Downstream raw materials:

(2-hydroxy-phenyl)-acetyl azide