41873-65-8

Basic information

• Product Name: ethyl (2-hydroxyphenyl)acetate
• Synonyms: (2-Hydroxyphenyl)acetic acid ethyl ester;2-Hydroxybenzeneacetic acid ethyl ester;Ethyl 2-(2-hydroxyphenyl)acetate;2-(2-Hydroxyphenyl)acetic Acid Ethyl Ester
• CAS NO: 41873-65-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2005
• EINECS: 255-572-6
• Product Categories: Aromatics;Intermediates
• Mol File: 41873-65-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 105°C@0.35-0.45mmHg.
• Flash Point: 115.3°C
• Appearance: /
• Density: 1.146g/cm³
• Vapor Pressure: 0.0026mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: -20?C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Store in Freezer
• CAS DataBase Reference: ethyl (2-hydroxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2-hydroxyphenyl)acetate(41873-65-8)
• EPA Substance Registry System: ethyl (2-hydroxyphenyl)acetate(41873-65-8)

Safety Data

• Hazardous Substances Data: 41873-65-8(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Liquid

Uses

Ethyl 2-Hydroxyphenylacetate is a useful synthetic intermediate for the preparation of novel antiinflammatory agents.

InChI:InChI=1/C10H12O3/c1-2-13-10(12)7-8-5-3-4-6-9(8)11/h3-6,11H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 101-97-3 Ethyl 2-phenylethanoate 
• 90-02-8 salicylaldehyde 
• 141-78-6 ethyl acetate 

Downstream Products

• 101790-50-5 2,4-bis-(2-hydroxy-phenyl)-acetoacetic acid ethyl ester 
• 156005-36-6 [2-(3-Bromo-propoxy)-phenyl]-acetic acid ethyl ester 
• 186135-55-7 4-Ethoxy-2H,5H-1-benzoxepin-2-one 
• 1104307-84-7 2-(2-ethoxy-2-oxoethyl)phenyl 2-(4-chlorophenyl)acetate 
• 1104307-99-4 2-(2-ethoxy-2-oxoethyl)phenyl 2-(3,4-dimethoxyphenyl)acetate 
• 1104307-90-5 2-(2-ethoxy-2-oxoethyl)phenyl 2-(3-chlorophenyl)acetate 
• 1104307-93-8 2-(2-ethoxy-2-oxoethyl)phenyl 2-(3-bromophenyl)acetate 
• 1104307-96-1 2-(2-ethoxy-2-oxoethyl)phenyl 2-(3-methoxyphenyl)acetate 
• 1104308-02-2 2-(2-ethoxy-2-oxoethyl)phenyl 2-(3,4-diethoxyphenyl)acetate 
• 1104308-05-5 2-(2-ethoxy-2-oxoethyl)phenyl 4-methylbenzoate 
• 1104308-14-6 2-(2-ethoxy-2-oxoethyl)phenyl 4-chlorobenzoate 
• 1104308-11-3 2-(2-ethoxy-2-oxoethyl)phenyl 2-chlorobenzoate 
• 1104308-08-8 2-(2-ethoxy-2-oxoethyl)phenyl 3-nitrobenzoate 
• 1104307-81-4 2-(2-ethoxy-2-oxoethyl)phenyl 2-(4-fluorophenyl)acetate 

Relevant articles and documents

Insights into Ruthenium(II/IV)-Catalyzed Distal C?H Oxygenation by Weak Coordination

C?H hydroxylation of aryl acetamides and alkyl phenylacetyl esters was accomplished via challenging distal weak O-coordination by versatile ruthenium(II/IV) catalysis. The ruthenium(II)-catalyzed C?H oxygenation of aryl acetamides proceeded through C?H ac

Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents

The first direct activator of BAX, a pro-apoptotic member of the BCL-2 family, has been recently identified. Herein, a structure-based lead optimization turned out into a small series of analogues, where 8 is the most potent compound published so far. 8 was used as pharmacological tool to ascertain, for the first time, the anticancer potential of BAX direct activators and the obtained results would suggest that BAX direct activators are potential future anticancer drugs rather than venoms.

Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes

First organocatalytic intramolecular aldolization of ortho-diacylbenzenes to construct highly functionalized 3-hydroxyindanones is described. In this transformation a high trans-selectivity is achieved by the use of metal salt of amino acid. This method allows an easy access to the strained spirocyclic 3-hydroxyindanones related to a number of natural product frameworks. Synthesis of a new class of indole skeleton substituted by 3-hydroxyindanones added an extra essence to this new protocol.