1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Base Information

Chemical Name:1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine
CAS No.:1356962-90-7
Molecular Formula:C₁₈H₂₈N₄O₃
Molecular Weight:348.445
Hs Code.:

Synonyms:1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

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Chemical Property of 1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

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Technology Process of 1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

There total 9 articles about 1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 109-01-3
1-methyl-piperazine

: 1356963-00-2
1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one

: 1356962-90-7
1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Guidance literature:: 1-methyl-piperazine; 1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one; With acetic acid; In methanol; at 20 ℃; for 2h;

With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield:

: 106579-00-4
5-methoxy-2-methyl-4-nitroaniline

: 1356962-90-7
1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen fluoride / pyridine / 0.17 h / -78 °C / Inert atmosphere

1.2: 2.17 h / -78 - 60 °C

2.1: potassium carbonate / dimethyl sulfoxide / 15 h / 80 °C

With hydrogen fluoride; potassium carbonate; In pyridine; dimethyl sulfoxide;

Reference yield:

: 452-78-8
3-fluoro-4-methyl phenol

: 1356962-90-7
1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid / dichloromethane / 1 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

4.1: toluene-4-sulfonic acid / water / 16 h / Reflux

5.1: acetic acid / methanol / 2 h / 20 °C

5.2: 20 °C

With nitric acid; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;