tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

Base Information

Chemical Name:tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate
CAS No.:1380228-99-8
Molecular Formula:C₁₅H₁₈F₂N₄O₄S
Molecular Weight:388.395
Hs Code.:

Synonyms:tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

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Chemical Property of tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

Chemical Property:

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Technology Process of tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

There total 6 articles about tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 137049-00-4
1-methyl-1H-imidazole-4-sulfonyl chloride

: 535170-20-8
tert-butyl (3-amino-2,6-difluorophenyl)carbamate

: 1380228-99-8
tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

Guidance literature:: With pyridine; In dichloromethane; at 50 ℃; for 2h;

Reference yield:

: 385-00-2
2,6-difluorobenzoic acid

: 1380228-99-8
tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; potassium nitrate / 24 h / 0 - 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

3.1: sodium azide / dichloromethane / 0.5 h / 20 °C

3.2: 3 h / Reflux

4.1: palladium on activated charcoal; hydrogen / methanol / 15 h

5.1: pyridine / dichloromethane / 2 h / 50 °C

With pyridine; sodium azide; oxalyl dichloride; sulfuric acid; palladium on activated charcoal; hydrogen; potassium nitrate; N,N-dimethyl-formamide; In methanol; dichloromethane;

Reference yield:

: 260552-98-5
2,6-difluoro-3-nitrobenzoic acid chloride

: 1380228-99-8
tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / dichloromethane / 0.5 h / 20 °C

1.2: 3 h / Reflux

2.1: palladium on activated charcoal; hydrogen / methanol / 15 h

3.1: pyridine / dichloromethane / 2 h / 50 °C

With pyridine; sodium azide; palladium on activated charcoal; hydrogen; In methanol; dichloromethane;