(3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

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Chemical Name:(3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine
CAS No.:1443773-75-8
Molecular Formula:C₃₉H₄₇NO₆
Molecular Weight:625.805
Hs Code.:

Synonyms:(3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

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Chemical Property of (3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

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Technology Process of (3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

There total 12 articles about (3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1443753-05-6
2-(4-iodophenyl)-4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromene

: 474527-76-9
(R)-2-(3-methylpyrrolidin-1-yl)ethanol

: 1443773-75-8
(3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

Guidance literature:: With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; at 120 ℃; for 91h; Inert atmosphere;

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 1443773-75-8
(3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: boron trifluoride diethyl etherate / toluene / 1.5 h / 100 - 108 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 0.75 h / -10 - 0 °C

3: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / iso-butanol / 50 - 130 °C / Dean-Stark

4: tetrahydrofuran / 1.5 h / 5 - 20 °C

5: acetic acid; water / 1.5 h / 90 °C / Inert atmosphere

6: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

7: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / 91 h / 120 °C / Inert atmosphere

With piperidine; copper(l) iodide; 1,10-Phenanthroline; boron trifluoride diethyl etherate; water; pyridinium p-toluenesulfonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; toluene; iso-butanol;

Reference yield:

: 108-46-3
recorcinol

: 1443773-75-8
(3R)-3-methyl-1-(2-(4-(4-methyl-7-((tetrahydro-2H-pyran-2-yl)oxy)-3-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: boron trifluoride diethyl etherate / toluene / 1.5 h / 100 - 108 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 0.75 h / -10 - 0 °C

3: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / iso-butanol / 50 - 130 °C / Dean-Stark

4: tetrahydrofuran / 1.5 h / 5 - 20 °C

5: acetic acid; water / 1.5 h / 90 °C / Inert atmosphere

6: pyridinium p-toluenesulfonate / dichloromethane / 20 °C

7: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / 91 h / 120 °C / Inert atmosphere

With piperidine; copper(l) iodide; 1,10-Phenanthroline; boron trifluoride diethyl etherate; water; pyridinium p-toluenesulfonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; toluene; iso-butanol;