8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Base Information

Chemical Name:8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one
CAS No.:1207454-51-0
Molecular Formula:C₂₅H₂₄N₄O
Molecular Weight:396.492
Hs Code.:

Synonyms:8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Chemical Property of 8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

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Technology Process of 8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

There total 7 articles about 8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1207453-44-8
3-(3-oxo-9-phenyl-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde

: 124-40-3
dimethyl amine

: 1207454-51-0
8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: 3-(3-oxo-9-phenyl-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzaldehyde; dimethyl amine; In methanol; at 20 ℃; for 0.666667h;

With sodium cyanoborohydride; acetic acid; In methanol; at 0 ℃; for 2h;

Reference yield:

: 626-19-7
Isophthalaldehyde

: 1207454-51-0
8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride / ethanol / 48 h / 40 °C

2.1: sodium sulfate / dichloromethane / 144 h / 0 - 20 °C

3.1: methanol / 24 h / 0 - 20 °C

4.1: hydrazine hydrate / methanol / 25 °C

5.1: hydrogenchloride / water / 3 h / 20 °C

6.1: methanol / 0.67 h / 20 °C

6.2: 2 h / 0 °C

With hydrogenchloride; ammonium chloride; hydrazine hydrate; sodium sulfate; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 150990-60-6
3-(diethoxymethyl)benzaldehyde

: 1207454-51-0
8-(3-((dimethylamino)methyl)phenyl)-9-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium sulfate / dichloromethane / 144 h / 0 - 20 °C

2.1: methanol / 24 h / 0 - 20 °C

3.1: hydrazine hydrate / methanol / 25 °C

4.1: hydrogenchloride / water / 3 h / 20 °C

5.1: methanol / 0.67 h / 20 °C

5.2: 2 h / 0 °C

With hydrogenchloride; hydrazine hydrate; sodium sulfate; In methanol; dichloromethane; water;