3-(4-pentylbenzamido)propanoic acid

Base Information

• Chemical Name: 3-(4-pentylbenzamido)propanoic acid
• CAS No.: 1421704-45-1
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 1421704-45-1.mol

Synonyms:3-(4-pentylbenzamido)propanoic acid

Chemical Property of 3-(4-pentylbenzamido)propanoic acid

Chemical Property:

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Technology Process of 3-(4-pentylbenzamido)propanoic acid

There total 1 articles about 3-(4-pentylbenzamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-pentylbenzoyl chloride (49763-65-7) + 3-amino propanoic acid (107-95-9) → 3-(4-pentylbenzamido)propanoic acid (1421704-45-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.1002/cmdc.201200350

Reference yield:

C23H40N4O6 + 3-(4-pentylbenzamido)propanoic acid (1421704-45-1) → C23H35N5O2 (1421704-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201200350

upstream raw materials:

4-pentylbenzoyl chloride

3-amino propanoic acid

Downstream raw materials:

C₂₃H₃₅N₅O₂