3-hydroxy-6-(hydroxymethyl)-2-[phenyl(phenylamino)methyl]-4H-pyran-4-one

Base Information

• Chemical Name: 3-hydroxy-6-(hydroxymethyl)-2-[phenyl(phenylamino)methyl]-4H-pyran-4-one
• CAS No.: 6290-96-6
• Molecular Formula: C19H17 N O4
• Molecular Weight: 323.3426

Synonyms:4H-Pyran-4-one,2-(a-anilinobenzyl)-3-hydroxy-6-(hydroxymethyl)-(6CI,8CI); NSC 1009

Chemical Property of 3-hydroxy-6-(hydroxymethyl)-2-[phenyl(phenylamino)methyl]-4H-pyran-4-one

Chemical Property:

• Vapor Pressure: 5.33E-15mmHg at 25°C
• Boiling Point: 594.9°C at 760 mmHg
• Flash Point: 313.6°C
• Density: 1.387g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

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Technology Process of 3-hydroxy-6-(hydroxymethyl)-2-[phenyl(phenylamino)methyl]-4H-pyran-4-one

There total 2 articles about 3-hydroxy-6-(hydroxymethyl)-2-[phenyl(phenylamino)methyl]-4H-pyran-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) + benzaldehyde (100-52-7) + aniline (62-53-3) → 3-hydroxy-6-(hydroxymethyl)-2-(phenyl(phenylamino)methyl)-4H-pyran-4-one (6290-96-6)

Guidance literature:

With toluene-4-sulfonic acid; In neat (no solvent); at 95 ℃; for 1.7h;

DOI:10.13005/ojc/290226

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → 3-hydroxy-6-(hydroxymethyl)-2-(phenyl(phenylamino)methyl)-4H-pyran-4-one (6290-96-6)

Guidance literature:

With pyridine;

DOI:10.1021/jo01112a606

Reference yield: 86.0%

3-hydroxy-6-(hydroxymethyl)-2-(phenyl(phenylamino)methyl)-4H-pyran-4-one (6290-96-6) + methyl iodide (74-88-4) → 6-(hydroxymethyl)-3-methoxy-2-(phenyl(phenylamino)methyl)-4H-pyran-4-one

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

DOI:10.1021/acs.jmedchem.0c01275

upstream raw materials:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

benzaldehyde

aniline

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