C₂₅H₂₂FNO₄

Base Information

• Chemical Name: C₂₅H₂₂FNO₄
• CAS No.: 1353554-56-9
• Molecular Formula: C₂₅H₂₂FNO₄
• Molecular Weight: 419.452
• Mol file: 1353554-56-9.mol

Synonyms:C₂₅H₂₂FNO₄

Chemical Property of C₂₅H₂₂FNO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₂FNO₄

There total 7 articles about C₂₅H₂₂FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

5-(6,7-dimethoxyquinolin-3-yl)-2,3-dimethoxyphenyl trifluoromethanesulfonate (1353555-66-4) + 4-fluoroboronic acid (1765-93-1) → C25H22FNO4 (1353554-56-9)

Guidance literature:

With potassium carbonate; palladium diacetate; XPhos; In 1,4-dioxane; water; at 95 ℃; for 3h; Inert atmosphere;

Reference yield:

3,4-dimethoxyaniline (6315-89-5) → C25H22FNO4 (1353554-56-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / ethanol; water / 12 h / Inert atmosphere; Reflux

1.2: pH 9

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 20 - 60 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / -78 - 0 °C / Inert atmosphere

5.1: potassium carbonate / palladium diacetate; XPhos / 1,4-dioxane; water / 3 h / 95 °C / Inert atmosphere

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; XPhos; In 1,4-dioxane; ethanol; dichloromethane; water; 2.1: Suzuki Coupling / 5.1: Suzuki Coupling;

Reference yield:

3-bromo-6,7-dimethoxyquinoline (850352-73-7) → C25H22FNO4 (1353554-56-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 5 h / 100 °C / Inert atmosphere

2: hydrogen; acetic acid / palladium 10% on activated carbon / 20 - 60 °C / 760.05 Torr

3: triethylamine / dichloromethane / -78 - 0 °C / Inert atmosphere

4: potassium carbonate / palladium diacetate; XPhos / 1,4-dioxane; water / 3 h / 95 °C / Inert atmosphere

With hydrogen; potassium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; palladium diacetate; XPhos; In 1,4-dioxane; dichloromethane; water; 1: Suzuki Coupling / 4: Suzuki Coupling;

upstream raw materials:

3,4-dimethoxyaniline

5-(6,7-dimethoxyquinolin-3-yl)-2,3-dimethoxyphenyl trifluoromethanesulfonate

4-fluoroboronic acid

3-bromo-6,7-dimethoxyquinoline

Downstream raw materials:

C₂₆H₂₅FNO₄⁽¹⁺⁾*I^(1-)