(E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

Base Information

• Chemical Name: (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide
• CAS No.: 1429292-13-6
• Molecular Formula: C₂₅H₂₃Cl₂F₃N₂O₄
• Molecular Weight: 543.37
• Mol file: 1429292-13-6.mol

Synonyms:(E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

Chemical Property of (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

There total 7 articles about (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)prop-2-ynyl)-2,5-dihydro-1H-pyrrole-3-carboxamide (1429293-60-6) → (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide (1429292-13-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol;

Reference yield:

N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-methoxy-5-oxo-1-(prop-2-ynyl)-2,5-dihydro-1H-pyrrole-3-carboxamide (1429293-59-3) → (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide (1429292-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

2: hydrogen; palladium on activated charcoal / methanol

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium on activated charcoal; hydrogen; diethylamine; triphenylphosphine; In methanol; N,N-dimethyl-formamide;

Reference yield:

4-(3,4-dichlorophenyl)butan-2-one (42160-40-7) → (E)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)allyl)-2,5-dihydro-1H-pyrrole-3-carboxamide (1429292-13-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonium acetate / methanol / 0.17 h / 20 °C

1.2: 18 h / 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / methanol / 0.17 h / 60 °C / Microwave irradiation

3.2: 0.25 h / 100 °C / Microwave irradiation

3.3: 18 h / 20 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine; triphenylphosphine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: hydrogen; palladium on activated charcoal / methanol

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium on activated charcoal; ammonium acetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

N-(4-(3,4-dichlorophenyl)butan-2-yl)-2-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-ylidene)acetamide

N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-methoxy-5-oxo-1-(prop-2-ynyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

N-(4-(3,4-dichlorophenyl)butan-2-yl)-4-hydroxy-5-oxo-1-(3-(4-(trifluoromethoxy)phenyl)prop-2-ynyl)-2,5-dihydro-1H-pyrrole-3-carboxamide

3(3,4-dichlorophenyl)propanoic acid