16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

Base Information

Chemical Name:16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one
CAS No.:106139-58-6
Molecular Formula:C₃₄H₄₆O₃Si
Molecular Weight:530.823
Hs Code.:

Synonyms:16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

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Chemical Property of 16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

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Technology Process of 16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

There total 3 articles about 16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53-16-7
Estrone

: 106139-58-6
16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / imidazole / dimethylformamide; ethyl acetate / 6 h / Ambient temperature

2: 1.) LDA / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, hexane, -20 deg C, 5 h

With 1H-imidazole; lithium diisopropyl amide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00378a015

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 106139-58-6
16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / imidazole / dimethylformamide; ethyl acetate / 6 h / Ambient temperature

2: 1.) LDA / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, hexane, -20 deg C, 5 h

With 1H-imidazole; lithium diisopropyl amide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00378a015

Reference yield:

: 79989-07-4
(E)-(4-bromo-but-2-enyloxy)-benzene

: 57711-40-7
3-(O-tert-butyl(dimethyl)silyl)estrone

: 106139-58-6
16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, hexane, -20 deg C, 5 h;
DOI:10.1021/jo00378a015