(2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

Chemical Name:(2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
CAS No.:1393085-32-9
Molecular Formula:C₂₁H₁₈N₂O₅
Molecular Weight:378.384
Hs Code.:

Synonyms:(2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Suppliers and Price of (2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Chemical Property:

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Technology Process of (2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

There total 5 articles about (2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.7%

: 1332881-55-6
(1-(phenylsulfonyl)-2-(1-(phenylsulfonyl)-1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

: 1393085-32-9
(2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm300564b

Reference yield:

: 80360-20-9
1-(phenylsulfonyl)indole-3-carbaldehyde

: 1393085-32-9
(2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With ammonium hydroxide; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; ethanol; water; mineral oil; pentane;
DOI:10.1021/jm300564b

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1393085-32-9
(2-(benzofuran-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol / 20 °C / Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: ammonium hydroxide / ethanol; water / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

4.2: -78 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

With ammonium hydroxide; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; potassium hydroxide; In tetrahydrofuran; ethanol; water; mineral oil; pentane;
DOI:10.1021/jm300564b