methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

Base Information

Chemical Name:methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate
CAS No.:1621254-12-3
Molecular Formula:C₃₆H₃₄F₆N₂O₇
Molecular Weight:720.666
Hs Code.:

methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

Synonyms:methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

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Chemical Property of methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

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Technology Process of methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

There total 6 articles about methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1402798-74-6
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methyl)-4-methyloxazolidin-2-one

: 85107-55-7
(4-(methoxycarbonyl)-2-nitrophenyl)boronic acid

: 1621254-12-3
methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

Guidance literature:: With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; In 1,2-dimethoxyethane; water; at 120 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1423044-99-8
(1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-chloro-2-methoxyphenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol

: 1621254-12-3
methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

2: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; water; 2: |Suzuki Coupling;

Reference yield:

: C₂₇H₂₈ClF₆NO₂

: 1621254-12-3
methyl 3'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-4'-methoxy-2-nitrobiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium cyanoborohydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane; water; 3: |Suzuki Coupling;