(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Base Information

Chemical Name:(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one
CAS No.:221343-63-1
Molecular Formula:C₁₉H₁₉NO₂
Molecular Weight:293.365
Hs Code.:

Synonyms:(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

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Chemical Property of (3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

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Technology Process of (3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

There total 7 articles about (3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 106-95-6
allyl bromide

: 474088-35-2
2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

: 221343-63-1
(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

: (3S)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: 2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

allyl bromide; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/S0040-4020(02)00462-3

Reference yield:

: C₁₉H₁₇NO₂

: 221343-63-1
(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: C₁₉H₁₇NO₂; With titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.5h; Inert atmosphere;

With triethylsilane; In dichloromethane; at -78 - 20 ℃; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2018.11.050

Reference yield:

: 191531-86-9
(3R,9bS)-3-Phenyl-2,3,5,9b-tetrahydro[1,3]oxazolo[2,3-a]isoindol-5-one

: 762-72-1
allyl-trimethyl-silane

: 221343-63-1
(3R)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

: (3S)-3-Allyl-2-[(1R)-2-hydroxy-1-phenylethyl]-2,3-dihydro-1H-isoindol-1-one

Guidance literature:: (3R,9bS)-3-Phenyl-2,3,5,9b-tetrahydro[1,3]oxazolo[2,3-a]isoindol-5-one; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 0.166667h;

allyl-trimethyl-silane; In dichloromethane; at -78 - 20 ℃; for 20.5h; Further stages.;
DOI:10.1039/b001569p