Technology Process of N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]-2-methoxy-pyridine-4-carbohydrazide
There total 8 articles about N'-[(E)-3-[4-(2-chlorophenyl)-5-(5-methylsulfonyl-2-pyridyl)-1,2,4-triazol-3-yl]prop-2-enoyl]-2-methoxy-pyridine-4-carbohydrazide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / Reflux
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
3.1: trimethylaluminum / toluene / 2 h / 80 - 90 °C
4.1: phosphorus pentachloride / benzene / Reflux
5.1: hydrazine hydrate / tetrahydrofuran / 0.67 h / 0 - 20 °C
6.1: toluene / 4 h / 20 °C / Reflux
7.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C
7.2: 1.5 h / -20 - 20 °C
With
oxalyl dichloride; phosphorus pentachloride; trimethylaluminum; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: thionyl chloride / 3 h / 20 °C / Reflux
1.2: pH 7
2.1: tetrahydrofuran / Reflux
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
4.1: trimethylaluminum / toluene / 2 h / 80 - 90 °C
5.1: phosphorus pentachloride / benzene / Reflux
6.1: hydrazine hydrate / tetrahydrofuran / 0.67 h / 0 - 20 °C
7.1: toluene / 4 h / 20 °C / Reflux
8.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C
8.2: 1.5 h / -20 - 20 °C
With
thionyl chloride; oxalyl dichloride; phosphorus pentachloride; trimethylaluminum; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / methanol / 2 h / 20 °C / Reflux
1.2: 0.5 h / Reflux
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C
2.2: 1.5 h / -20 - 20 °C
With
thionyl chloride; oxalyl dichloride;
N,N-dimethyl-formamide;
In
methanol; dichloromethane;
