tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Base Information

Chemical Name:tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate
CAS No.:1361323-33-2
Molecular Formula:C₂₆H₄₂N₄O₆S
Molecular Weight:538.709
Hs Code.:

Synonyms:tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

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Chemical Property of tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

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Technology Process of tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

There total 7 articles about tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1361323-32-1
tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

: 98-09-9
benzenesulfonyl chloride

: 1361323-33-2
tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 876379-22-5
benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

: 1361323-33-2
tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

2.2: 20 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

4.2: 0.08 h

4.3: 0 - 20 °C

5.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; ammonium formate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 876461-55-1
(S)-benzyl 3-aminopiperidine-1-carboxylate hydrochloride

: 1361323-33-2
tert-butyl (S)-1-((S)-3,3-dimethyl-1-oxo-1-((S)-1-(phenylsulfonyl)piperidin-3-ylamino)butan-2-ylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

3.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 0 °C

3.2: 0.08 h

3.3: 0 - 20 °C

4.1: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; ammonium formate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.12.109