5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

Base Information

Chemical Name:5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile
CAS No.:1070973-29-3
Molecular Formula:C₁₄H₈ClF₃N₂O
Molecular Weight:312.679
Hs Code.:

Synonyms:5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

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Chemical Property of 5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

Chemical Property:

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Technology Process of 5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

There total 5 articles about 5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070892-04-4
5-bromo-2-trifluoromethylisonicotinonitrile

: 219735-99-6
2-chloro-4-methoxyphenylboronic acid

: 1070973-29-3
5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 85 ℃; for 6h;

Reference yield:

: 1070972-53-0
C₇H₂BrClF₃NO

: 1070973-29-3
5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / water; acetonitrile / 0.33 h

2.1: trichlorophosphate / 3 h / 70 °C

2.2: 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C

With ammonia; sodium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1070892-03-3
5-bromo-2-trifluoromethylisonicotinamide

: 1070973-29-3
5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 3 h / 70 °C

1.2: 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 6 h / 85 °C

With sodium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water;