R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE
• CAS No.: 89874-80-6
• Molecular Formula: C14H21 N O . Cl H
• Molecular Weight: 255.788
• Hs Code.: 2933399090
• Mol file: 89874-80-6.mol

Synonyms:Phenol,3-(1-propyl-3-piperidinyl)-, hydrochloride, (R)- (9CI); R(+)-3-PPP-HCL

Chemical Property of R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 3.85E-05mmHg at 25°C
• Boiling Point: 342.2°C at 760 mmHg
• Flash Point: 158°C
• PSA: 23.47000
• LogP: 3.72150
• Solubility.: H2O: 150 mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE

There total 6 articles about R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(+)-(S)-3-(3-methoxyphenyl)-1-propylpiperidine (89874-51-1) → (+)-3-PPP hydrochloride (89874-80-6)

Guidance literature:

With hydrogen bromide; at 120 ℃; for 4h;

DOI:10.1016/S0040-4020(01)83477-3

Reference yield:

(3-methoxyphenyl)magnesium bromide (36282-40-3) → (+)-3-PPP hydrochloride (89874-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 76.5 percent / dichlorobis(triphenylphosphine)nickel (II) / tetrahydrofuran / 24 h / Ambient temperature

2: acetone / 20 h / 100 °C / in high pressure vessel

3: H₂ / 5percent PtO₂/C / methanol / 24 h / Ambient temperature

4: 75 percent / 48percent HBr / 4 h / 120 °C

With hydrogen bromide; hydrogen; PtO₂/C; bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/S0040-4020(01)83477-3

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → (+)-3-PPP hydrochloride (89874-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 76.5 percent / dichlorobis(triphenylphosphine)nickel (II) / tetrahydrofuran / 24 h / Ambient temperature

2: acetone / 20 h / 100 °C / in high pressure vessel

3: H₂ / 5percent PtO₂/C / methanol / 24 h / Ambient temperature

4: 75 percent / 48percent HBr / 4 h / 120 °C

With hydrogen bromide; hydrogen; PtO₂/C; bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; methanol; acetone;

DOI:10.1016/S0040-4020(01)83477-3

upstream raw materials:

(+)-(S)-3-(3-methoxyphenyl)-1-propylpiperidine

3-Bromopyridine

3-(3-methoxyphenyl)pyridine

(3-methoxyphenyl)magnesium bromide

Downstream raw materials:

(-)-3-<3-<(methoxyethoxy)methoxy>phenyl>-N-propylpiperidine

(-)-3-<3-(decanoyloxy)phenyl>-N-propylpiperidine