89874-51-1

Basic information

• Product Name: Piperidine, 3-(3-methoxyphenyl)-1-propyl-, (S)-
• CAS NO: 89874-51-1
• Molecular Formula: C15H23NO
• Molecular Weight: 233.354
• Mol File: 89874-51-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Piperidine, 3-(3-methoxyphenyl)-1-propyl-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 3-(3-methoxyphenyl)-1-propyl-, (S)-(89874-51-1)
• EPA Substance Registry System: Piperidine, 3-(3-methoxyphenyl)-1-propyl-, (S)-(89874-51-1)

Safety Data

• Hazardous Substances Data: 89874-51-1(Hazardous Substances Data)

Upstream product

• 106-94-5 propyl bromide 
• 88784-37-6 (+)-(S)-3-(3-methoxyphenyl)piperidine 
• 85966-89-8 preclamol 
• 77-78-1 dimethyl sulfate 
• 4373-67-5 3-(3-methoxyphenyl)pyridine 
• 3105-95-1 pipecolinic acid 
• 596121-81-2 dibenzyl 2-bromopentanedioate 
• 181705-90-8 (3-methoxyphenyl)zinc(II) bromide 
• 2398-37-0 3-methoxyphenyl bromide 
• 626-20-0 3-methoxystyrene 
• 107-10-8 propylamine 
• 107-08-4 1-iodo-propane 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 79601-21-1 3-(3-methoxyphenylpiperidine) 

Downstream Products

• 85966-89-8 preclamol 
• 85976-54-1 (+)-preclamol 
• 146798-88-1 S-(-)-3-<(3-(((trifluoromethyl)sulfonyl)oxy)phenyl)-N-n-propyl>piperidine 
• 1071930-35-2 trifluoromethanesulfonic acid 3-((S)-1-propyl-1-oxo-piperidin-3-yl)-phenyl ester 
• 147161-65-7 (S)-N-propyl-3-(3-methoxy-4-aminophenyl)piperidine 
• 147161-63-5 (S)-N-propyl-3-(3-methoxy-4-nitrophenyl)piperidine 
• 89874-80-6 (+)-3-PPP hydrochloride 

Relevant articles and documents

Method for asymmetrically synthesizing (S)-preclamol

The invention discloses a novel method for asymmetrically synthesizing (S)-preclamol. The method comprises the following steps: using racemic alpha-halogenated glutaric acid diester as a starting material to be subjected to an asymmetric Negishi cross-coupling reaction with zinc m-methoxyphenyl bromide under the catalysis of a bisoxazoline chiral ligand and metal cobalt to obtain m-methoxyphenyl-substituted glutaric acid diester, then reducing by LiAlH4 to form (S)-2-(3-methoxyphenyl) pentanediol, and finally performing to amination cyclization and desmethylation to obtain (S)-preclamol. The asymmetric Negishi cross-coupling reaction is utilized for the first time to directly construct the chiral center of (S)-preclamol, the synthesis route is short, the reaction conditions are mild, and the total yield is 51%.

Stereoselective synthesis of (?)-3-PPP through palladium-catalysed unactivated C(sp3)–H arylation at the C-3 position of L-pipecolinic acid

An efficient route for the preparation of (?)-3-PPP(preclamol) using the highly stereoselective palladium-catalysed C(sp3)-H arylation and radical decarboxylation reaction as the key steps is described. The chiral center at the C-3 position of

N-OXIDE AND/OR DI-N-OXIDE DERIVATIVES OF DOPAMINE RECEPTOR STABILIZERS/MODULATORS DISPLAYING IMPROVED CARDIOVASCULAR SIDE-EFFECTS PROFILES

The invention relates to N-oxide and/or di-N-oxide derivatives of dopamine receptor stabilizers/modulators having the general formula (1) or (2) and pharmaceutical preparations containing the said compounds. Further, the invention relates the use of the s