6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

Base Information

Chemical Name:6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine
CAS No.:103959-87-1
Molecular Formula:C₃₁H₂₄ClN₅O₇S
Molecular Weight:646.08
Hs Code.:

Synonyms:6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

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Chemical Property of 6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

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Technology Process of 6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

There total 6 articles about 6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 103980-83-2
6-amino-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

: 103959-87-1
6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

Guidance literature:: With tert.-butylnitrite; antimony(III) chloride; In 1,2-dichloro-ethane; at -10 ℃; for 2.5h;
DOI:10.1021/jm00161a017

Reference yield:

: 23316-68-9
(2R,3R,4R,5R)-3,4-bis(benzoyloxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2-carboxylic acid

: 103959-87-1
6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / ethanol; H₂O / 18 h / 60 - 70 °C

2: ethane-1,2-diol / 2 h

3: 70 percent / P₂S₅, 4-(N,N-dimethylamino)pyridine / dioxane / 1.17 h / Heating

4: 1.) NaH / 1.) DMF, CH₂Cl₂, RT, 30 min, 2.) DMF, CH₂Cl₂, RT, 18 h

5: 77 percent / SbCl₃, tert-butyl nitrite / 1,2-dichloro-ethane / 2.5 h / -10 °C

With dmap; tert.-butylnitrite; tetraphosphorus decasulfide; antimony(III) chloride; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In 1,4-dioxane; ethanol; water; ethylene glycol; 1,2-dichloro-ethane;
DOI:10.1021/jm00161a017

Reference yield:

: 67560-74-1
3,4,6-tri-O-benzoyl-2,5-anhydro-D-allonic acid chloride

: 103959-87-1
6-chloro-8-(methylthio)-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<3,4-f>-1,2,4-triazine

Guidance literature:: Multi-step reaction with 5 steps

1: KOH / H₂O; tetrahydrofuran / 0.5 h

2: ethane-1,2-diol / 2 h

3: 70 percent / P₂S₅, 4-(N,N-dimethylamino)pyridine / dioxane / 1.17 h / Heating

4: 1.) NaH / 1.) DMF, CH₂Cl₂, RT, 30 min, 2.) DMF, CH₂Cl₂, RT, 18 h

5: 77 percent / SbCl₃, tert-butyl nitrite / 1,2-dichloro-ethane / 2.5 h / -10 °C

With dmap; potassium hydroxide; tert.-butylnitrite; tetraphosphorus decasulfide; antimony(III) chloride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; water; ethylene glycol; 1,2-dichloro-ethane;
DOI:10.1021/jm00161a017