4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

Base Information

Chemical Name:4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene
CAS No.:1433749-82-6
Molecular Formula:C₃₆H₅₂O₁₀Si
Molecular Weight:672.888
Hs Code.:

Synonyms:4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

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Chemical Property of 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

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Technology Process of 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

There total 4 articles about 4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

: 183133-98-4
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-9-oxo-10β-methoxy-7β,13α-di(triethylsilyloxy)-11-taxene

: 1433749-82-6
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere;

Reference yield:

: 32981-86-5,172018-16-5
10-deacetylbaccatin III

: 1433749-82-6
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / -5 - 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 994-30-9
triethylsilyl chloride

: 1433749-82-6
4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β-dihydroxy-9-oxo-10β-methoxy-13α-triethylsilyloxy-11-taxene

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / -5 - 0 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 5 °C / Inert atmosphere

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane;