methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

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Chemical Name:methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate
CAS No.:1367875-01-1
Molecular Formula:C₃₉H₃₈N₄O₄
Molecular Weight:626.755
Hs Code.:

Synonyms:methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

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Technology Process of methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

There total 8 articles about methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1246350-28-6
4-(cyclohexyloxy)-3-iodo-1-trityl-1H-pyrazolo[4,3-c]pyridine

: 1367830-46-3
methyl 1-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H pyrrole-2-carboxylate

: 1367875-01-1
methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

Guidance literature:: With potassium acetate; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; In water; acetonitrile; at 145 ℃; for 0.666667h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 134031-24-6
2,4-dichloro-3-pyridine Carboxaldehyde

: 1367875-01-1
methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

2.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 19 h / 20 °C

4.1: sodium hydride / 1,4-dioxane; mineral oil / 1 h / 20 °C

4.2: 1.5 h / 180 °C / Microwave irradiation

5.1: potassium acetate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / water; acetonitrile / 0.67 h / 145 °C / Microwave irradiation; Inert atmosphere

With iodine; potassium acetate; sodium hydride; hydrazine hydrate; potassium hydroxide; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1367875-01-1
methyl 1-isopropyl-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3.5 h / -78 - 0 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 19 h / 20 °C

5.1: sodium hydride / 1,4-dioxane; mineral oil / 1 h / 20 °C

5.2: 1.5 h / 180 °C / Microwave irradiation

6.1: potassium acetate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / water; acetonitrile / 0.67 h / 145 °C / Microwave irradiation; Inert atmosphere

With n-butyllithium; iodine; potassium acetate; sodium hydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;