(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

Base Information

Chemical Name:(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester
CAS No.:134958-85-3
Molecular Formula:C₂₇H₃₁NO₅
Molecular Weight:449.547
Hs Code.:

Synonyms:(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

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Chemical Property of (1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

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Technology Process of (1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

There total 4 articles about (1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 134958-84-2
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid phenethyl ester

: 1885-14-9
phenyl chloroformate

: 134958-85-3
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h; Heating;
DOI:10.1016/S0040-4020(01)81785-3

Reference yield:

: 60-12-8
2-phenylethanol

: 134958-85-3
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / DMAP / CH₂Cl₂ / 66 h / Heating

2: 1) LIBH₄, 2) TFA, Et₃SiH / 1) THF, 0 deg C, 4h, 2) CH₂Cl₂, 3.5h

3: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Heating

With triethylsilane; dmap; lithium borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(01)81785-3

Reference yield:

: 109216-50-4
(1S,5R,7S)-1,5,7-Trimethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carbonyl chloride

: 134958-85-3
(1R,5S,7S)-1,5,7-Trimethyl-2-oxo-3-aza-bicyclo[3.3.1]nonane-3,7-dicarboxylic acid 7-phenethyl ester 3-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / DMAP / CH₂Cl₂ / 66 h / Heating

2: 1) LIBH₄, 2) TFA, Et₃SiH / 1) THF, 0 deg C, 4h, 2) CH₂Cl₂, 3.5h

3: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 15 h / Heating

With triethylsilane; dmap; lithium borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4020(01)81785-3