2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid

Base Information

• Chemical Name: 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid
• CAS No.: 1398122-57-0
• Molecular Formula: C₅₅H₅₆N₂O₅S
• Molecular Weight: 857.126
• Mol file: 1398122-57-0.mol

Synonyms:2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid

Chemical Property of 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid

There total 4 articles about 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.2%

5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophene-2-carbaldehyde (1398122-56-9) + cyanoacetic acid (372-09-8) → 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid (1398122-57-0)

Guidance literature:

With piperidine; In chloroform; for 12h; Reflux; Inert atmosphere;

DOI:10.1039/c2jm33105e

Reference yield:

4-(2-ethylhexyloxy)-N-(4-(2-ethylhexyloxy)phenyl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzeneamine (1314556-70-1) → 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid (1398122-57-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene / 24 h / Reflux; Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; methanol / 2 h / Reflux; Inert atmosphere; Microwave irradiation

3: piperidine / chloroform / 12 h / Reflux; Inert atmosphere

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; chloroform; toluene; 1: |Suzuki Coupling / 2: |Suzuki Coupling / 3: |Knoevenagel Condensation;

DOI:10.1039/c2jm33105e

Reference yield:

4-bromo-N,N-bis((4-(2-ethyl)hexyloxy)phenyl)aniline (1192035-51-0) → 2-cyano-3-(5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophen-2-yl)acrylic acid (1398122-57-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; water / 16 h / Inert atmosphere; Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; water / 24 h / Inert atmosphere; Reflux

4.1: piperidine / chloroform / 12 h / Inert atmosphere; Reflux

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; chloroform; water; toluene; 4.1: |Knoevenagel Condensation;

upstream raw materials:

5-(7-(4-(N,N-bis(4-((2-ethylhexyl)oxy)phenyl)amino)phenyl)-9-oxo-9H-fluoren-2-yl)thiophene-2-carbaldehyde

cyanoacetic acid

4-(2-ethylhexyloxy)-N-(4-(2-ethylhexyloxy)phenyl)-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzeneamine

4-bromo-N,N-bis((4-(2-ethyl)hexyloxy)phenyl)aniline