(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Base Information

Chemical Name:(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide
CAS No.:128632-99-5
Molecular Formula:C₄₁H₅₉N₇O₅
Molecular Weight:729.963
Hs Code.:

(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Synonyms:(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

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Chemical Property of (2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

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Technology Process of (2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

There total 15 articles about (2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.2%

: 96-17-3,57456-98-1
2-Methylbutyraldehyde

: 128633-36-3
(2R,5S,14S)-14-Amino-2-benzyl-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

: 128632-99-5
(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: With sodium cyanoborohydride; In methanol; Ambient temperature;
DOI:10.1021/jm00171a033

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 128632-99-5
(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 9 steps

1: dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide / 1.) 4 deg C, 48 h, 2.) RT, 3 days

2: ammonium formate / 10percent Pd-C / methanol

3: dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide / 1.) 4 deg C, 48 h, 2.) RT, 3 days

4: 90.7 percent / 1N HCl, acetic acid / 1 h

5: 60.3 percent / NaHCO₃, diphenyl phosphorazidate / dimethylformamide

6: 2N aq. NaOH / methanol

7: 78.8 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide / 1.) 4 deg C, 48 h, 2.) RT, 3 days

8: H₂ / 5percent Pd-C

9: 51.2 percent / sodium cyanoborohydride / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; diphenyl phosphoryl azide; hydrogen; ammonium formate; sodium cyanoborohydride; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a033

Reference yield:

: 107-85-7
1-amino-3-methylbutane

: 128632-99-5
(2R,5S,14S)-2-Benzyl-14-(2-methyl-butylamino)-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 78.8 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), triethylamine / dimethylformamide / 1.) 4 deg C, 48 h, 2.) RT, 3 days

2: H₂ / 5percent Pd-C

3: 51.2 percent / sodium cyanoborohydride / methanol / Ambient temperature

With hydrogen; sodium cyanoborohydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a033