tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate

Base Information

• Chemical Name: tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate
• CAS No.: 690653-25-9
• Molecular Formula: C₁₄H₁₇F₄NO₂
• Molecular Weight: 307.288
• Mol file: 690653-25-9.mol

Synonyms:tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate

Chemical Property of tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate

There total 2 articles about tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

C13H15F4NO2 (690653-24-8) → tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate (690653-25-9)

Guidance literature:

With sodium hydride; methyl iodide; In DMF (N,N-dimethyl-formamide); at -78 - 20 ℃; for 0.5h;

Reference yield: 47.0%

di-tert-butyl dicarbonate (24424-99-5) + methylamine (74-89-5) + 3-fluoro-5-(trifluoromethyl)benzaldehyde (188815-30-7) → tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate (690653-25-9)

Guidance literature:

methylamine; 3-fluoro-5-(trifluoromethyl)benzaldehyde; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 0.5h;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 94.3%

tert-butyl 3-fluoro-5-(trifluoromethyl)benzyl(methyl)carbamate (690653-25-9) → {[3-fluoro-5-(trifluoromethyl)phenyl]methyl}(methyl)amine (690653-23-7)

Guidance literature:

With hydrogenchloride; water; In 1,3-dioxane;

upstream raw materials:

C₁₃H₁₅F₄NO₂

di-tert-butyl dicarbonate

methylamine

3-fluoro-5-(trifluoromethyl)benzaldehyde

Downstream raw materials:

{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}(methyl)amine