11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

Base Information

Chemical Name:11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene
CAS No.:1049088-69-8
Molecular Formula:C₂₇H₂₇FN₂O₄S
Molecular Weight:494.587
Hs Code.:

Synonyms:11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

There total 2 articles about 11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 59649-56-8
2,3-diaminophenol

: 504414-32-8
4-(benzyloxy)-2-fluorobenzaldehyde

: 1049093-43-7
C₇H₁₂O₃S

: 1049088-69-8
11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

: 1049088-70-1
11-(4-benzyloxy-2-fluorophenyl)-9-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

Guidance literature:: 2,3-diaminophenol; C₇H₁₂O₃S; With trifluoroacetic acid; In N,N-dimethyl-formamide; at 20 - 50 ℃; Molecular sieve;

4-(benzyloxy)-2-fluorobenzaldehyde; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 50 ℃; Molecular sieve;
DOI:10.1021/jm9005548

Reference yield:

: 504414-32-8
4-(benzyloxy)-2-fluorobenzaldehyde

: 1049093-48-2
C₁₃H₁₈N₂O₃S

: 1049093-94-8
C₁₃H₁₈N₂O₃S

: 1049088-69-8
11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

: 1049088-70-1
11-(4-benzyloxy-2-fluorophenyl)-9-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

Guidance literature:: With sodium hydrogencarbonate; at 50 ℃; for 12h;

Reference yield: 82.0%

: 126125-54-0
6-methyl-pyridine-2-carbonyl chloride

: 1049088-69-8
11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

: 1049088-76-7
11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-10-(6-methyl-2-pyridylcarbonyl)-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene

Guidance literature:: 6-methyl-pyridine-2-carbonyl chloride; 11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-1,1-dioxo-1,2,3,4,5,11-hexahydro-1λ6-thia-5,10-diazadibenzo[a,d]cycloheptene; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;
DOI:10.1021/jm9005548