N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Base Information

Chemical Name:N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine
CAS No.:1414853-79-4
Molecular Formula:C₃₁H₄₁N₃O₁₄S
Molecular Weight:711.744
Hs Code.:

N<SUP>3</SUP>-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Synonyms:N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Suppliers and Price of N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

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Technology Process of N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

There total 8 articles about N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 1414853-72-7
N³-Boc-2'-O-p-nitrophenylsulfonyl-5-methyluridine

: 1414853-79-4
N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2012.10.001

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1414853-79-4
N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 12 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 0 - 20 °C

3: toluene-4-sulfonic acid / tetrahydrofuran / 16 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2012.10.001

Reference yield:

: 130983-87-8
1-[(6aR,8R,9S,9aR)-tetrahydro-9-hydroxy-2,2,4,4-tetraisopropyl-6H-furo[3,2-f]-[1,3,5,2,4]trioxadisilocin-8-yl](5-methylpyrimidine)-2.4(1H_.3H)-dione

: 1414853-79-4
N³-Boc-3',5'-O-bis-tetrahydropyranyl-2'-O-p-nitrophenylsulfonyl-5-methyluridine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 0 °C

2: dmap

3: toluene-4-sulfonic acid / tetrahydrofuran

4: pyridine / dichloromethane / 12 h / 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 0 - 20 °C

6: toluene-4-sulfonic acid / tetrahydrofuran / 16 h / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2012.10.001