(7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester

Base Information

• Chemical Name: (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester
• CAS No.: 128184-08-7
• Molecular Formula: C₃₉H₅₆N₄O₆
• Molecular Weight: 676.897

Synonyms:(7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester

Chemical Property of (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester

There total 8 articles about (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

(15-Bromo-7,11-bis-tert-butoxycarbonylmethyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-3-yl)-acetic acid tert-butyl ester (128184-07-6) + phenylacetylene (536-74-3) → (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-3-yl)-acetic acid tert-butyl ester (128184-08-7)

Guidance literature:

With triethylamine; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran; at 45 ℃; for 24h;

Reference yield:

bis(3-aminopropyl)amine (56-18-8) → (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-3-yl)-acetic acid tert-butyl ester (128184-08-7)

Guidance literature:

Multi-step reaction with 3 steps

2: 39 percent / potassium carbonate / acetonitrile / 24 h / Ambient temperature

3: 63 percent / triethylamine / bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide / tetrahydrofuran / 24 h / 45 °C

With potassium carbonate; triethylamine; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran; acetonitrile;

Reference yield:

4-bromo pyridine-2,6-dicarbaldehyde (128184-01-0) → (7,11-Bis-tert-butoxycarbonylmethyl-15-phenylethynyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1(16),13(17),14-trien-3-yl)-acetic acid tert-butyl ester (128184-08-7)

Guidance literature:

Multi-step reaction with 3 steps

2: 39 percent / potassium carbonate / acetonitrile / 24 h / Ambient temperature

3: 63 percent / triethylamine / bis(triphenylphosphine)palladium(II) chloride, copper(I) iodide / tetrahydrofuran / 24 h / 45 °C

With potassium carbonate; triethylamine; copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; In tetrahydrofuran; acetonitrile;

upstream raw materials:

(15-Bromo-7,11-bis-tert-butoxycarbonylmethyl-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-3-yl)-acetic acid tert-butyl ester

phenylacetylene

bis(3-aminopropyl)amine

4-bromo pyridine-2,6-dicarbaldehyde

Downstream raw materials:

15-(phenylethynyl)-3,7,11-tris(carboxymethyl)-3,7,11,17-tetraazabicyclo<11.3.1>heptadeca-1(17),13,15-triene

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