128184-01-0Relevant articles and documents
COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS
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, (2019/10/29)
The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates to these activator compounds for use in a method for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3',5-adenosine monophosphate (cAMP).
Azobenzene-Equipped Covalent Organic Framework: Light-Operated Reservoir
Das, Gobinda,Prakasam, Thirumurugan,Addicoat, Matthew A.,Sharma, Sudhir Kumar,Ravaux, Florent,Mathew, Renny,Baias, Maria,Jagannathan, Ramesh,Olson, Mark A.,Trabolsi, Ali
, p. 19078 - 19087 (2019/11/28)
Light-operated materials have gained significant attention for their potential technological importance. To achieve molecular motion within extended networks, stimuli-responsive units require free space. The majority of the so far reported 2D-extended org
Formation of a hetero[3]rotaxane by a dynamic component-swapping strategy
Wilson, Eleanor A.,Vermeulen, Nicolaas A.,McGonigal, Paul R.,Avestro, Alyssa-Jennifer,Sarjeant, Amy A.,Stern, Charlotte L.,Stoddart, J. Fraser
supporting information, p. 9665 - 9668 (2014/08/18)
Acid-catalysed scrambling of the mechanically interlocked components between two different homo[3]rotaxanes, constituted of dumbbells containing two secondary dialkylammonium ion recognition sites encircled by two [24]crown-8 rings, each containing a couple of imine bonds, affords a statistical mixture of a hetero[3]rotaxane along with the two homo[3]rotaxanes, indicating that neither selectivity nor cooperativity is operating during the assembly process. This journal is the Partner Organisations 2014.
A convenient approach for the synthesis of 2,6-diformyl- and 2,6-diacetylpyridines
Ivchenko, Pavel V.,Nifant'Ev, Ilya E.,Buslov, Ivan V.
supporting information, p. 217 - 219 (2013/02/23)
2,6-Diformyl- and 2,6-diacetylpyridines are readily accessed in good yields (60-90%) via the single-pot reaction of 2,6-pyridine dicarboxamides with LiAlH4 or MeMgCl in THF at 0-20°C. The high efficiency of the method illustrates the significance of solubility in the reduction and alkylation of difunctionalized substrates.
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic
Kelso, Geoffrey F.,Smith, Robin A. J.,Maroz, Andrej,Anderson, Robert F.,Cocheme, Helena M.,Logan, Angela,Prime, Tracy A.,James, Andrew M.,Ross, Meredith F.,Murphy, Michael P.,Peskin, Alexander V.,Winterbourn, Christine C.,Brooker, Sally,Porteous, Carolyn M.
, p. 1237 - 1246,10 (2020/08/24)
Superoxide (O2s-) is the proximal mitochondrial reactive oxygen species underlying pathology and redox signaling. This central role prioritizes development of a mitochondria-targeted reagent selective for controlling O2s-. We have conjugated a mitochondria-targeting triphenylphosphonium (TPP) cation to a O2 s--selective pentaaza macrocyclic Mn(II) superoxide dismutase (SOD) mimetic to make MitoSOD, a mitochondria-targeted SOD mimetic. MitoSOD showed rapid and extensive membrane potential-dependent uptake into mitochondria without loss of Mn and retained SOD activity. Pulse radiolysis measurements confirmed that MitoSOD was a very effective catalytic SOD mimetic. MitoSOD also catalyzes the ascorbate-dependent reduction of O2s-. The combination of mitochondrial uptake and O2s- scavenging by MitoSOD decreased inactivation of the matrix enzyme aconitase caused by O2s-. MitoSOD is an effective mitochondria-targeted macrocyclic SOD mimetic that selectively protects mitochondria from O2s- damage.
Template-directed synthesis of multiply mechanically interlocked molecules under thermodynamic control
Arico, Fabio,Chang, Theresa,Cantrill, Stuart J.,Khan, Saeed I.,Stoddart, J. Fraser
, p. 4655 - 4666 (2007/10/03)
The template-directed construction of crown-ether-like macrocycles around secondary dialkylammonium ions (R2NH2+) has been utilized for the expedient (one-pot) and high-yielding synthesis of a diverse range of mechanically
Mitochondrially targeted antioxidants
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Page/Page column 7-8, (2010/02/05)
The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compoun
Preparation of New Macrocyclic Polyamines Containing 4-(Phenylethynyl)pyridine Subunit
Takalo, Harri,Kankare, Jouko
, p. 167 - 169 (2007/10/02)
Two new tetraazacycloalkane-N-acetic acids containing 4-(phenylethynyl)pyridine subunit as a part of macrocycle have been prepared.Two methods for the cyclisation reaction were investigated.