128184-01-0Relevant articles and documents
Azobenzene-Equipped Covalent Organic Framework: Light-Operated Reservoir
Das, Gobinda,Prakasam, Thirumurugan,Addicoat, Matthew A.,Sharma, Sudhir Kumar,Ravaux, Florent,Mathew, Renny,Baias, Maria,Jagannathan, Ramesh,Olson, Mark A.,Trabolsi, Ali
supporting information, p. 19078 - 19087 (2019/11/28)
Light-operated materials have gained significant attention for their potential technological importance. To achieve molecular motion within extended networks, stimuli-responsive units require free space. The majority of the so far reported 2D-extended org
Formation of a hetero[3]rotaxane by a dynamic component-swapping strategy
Wilson, Eleanor A.,Vermeulen, Nicolaas A.,McGonigal, Paul R.,Avestro, Alyssa-Jennifer,Sarjeant, Amy A.,Stern, Charlotte L.,Stoddart, J. Fraser
, p. 9665 - 9668 (2014/08/18)
Acid-catalysed scrambling of the mechanically interlocked components between two different homo[3]rotaxanes, constituted of dumbbells containing two secondary dialkylammonium ion recognition sites encircled by two [24]crown-8 rings, each containing a couple of imine bonds, affords a statistical mixture of a hetero[3]rotaxane along with the two homo[3]rotaxanes, indicating that neither selectivity nor cooperativity is operating during the assembly process. This journal is the Partner Organisations 2014.
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic
Kelso, Geoffrey F.,Smith, Robin A. J.,Maroz, Andrej,Anderson, Robert F.,Cocheme, Helena M.,Logan, Angela,Prime, Tracy A.,James, Andrew M.,Ross, Meredith F.,Murphy, Michael P.,Peskin, Alexander V.,Winterbourn, Christine C.,Brooker, Sally,Porteous, Carolyn M.
, p. 1237 - 1246,10 (2020/08/24)
Superoxide (O2s-) is the proximal mitochondrial reactive oxygen species underlying pathology and redox signaling. This central role prioritizes development of a mitochondria-targeted reagent selective for controlling O2s-. We have conjugated a mitochondria-targeting triphenylphosphonium (TPP) cation to a O2 s--selective pentaaza macrocyclic Mn(II) superoxide dismutase (SOD) mimetic to make MitoSOD, a mitochondria-targeted SOD mimetic. MitoSOD showed rapid and extensive membrane potential-dependent uptake into mitochondria without loss of Mn and retained SOD activity. Pulse radiolysis measurements confirmed that MitoSOD was a very effective catalytic SOD mimetic. MitoSOD also catalyzes the ascorbate-dependent reduction of O2s-. The combination of mitochondrial uptake and O2s- scavenging by MitoSOD decreased inactivation of the matrix enzyme aconitase caused by O2s-. MitoSOD is an effective mitochondria-targeted macrocyclic SOD mimetic that selectively protects mitochondria from O2s- damage.