Nisoxetine hydrochloride, (+)-

Base Information

Chemical Name:Nisoxetine hydrochloride, (+)-
CAS No.:114446-53-6
Molecular Formula:C₁₇H₂₁NO₂*ClH
Molecular Weight:307.82
Hs Code.:
UNII:22NZ2QEN9S

Synonyms:Nisoxetine hydrochloride, (+)-;UNII-22NZ2QEN9S;22NZ2QEN9S;114446-53-6;Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, hydrochloride, (R)-;Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-, hydrochloride (1:1), (gammaR)-;(+)-nisoxetine hydrochloride;Q27253661;BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, HYDROCHLORIDE, (R)-;BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, HYDROCHLORIDE (1:1), (.GAMMA.R)-

Suppliers and Price of Nisoxetine hydrochloride, (+)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Nisoxetine hydrochloride, (+)-

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:307.1339066
Heavy Atom Count:21
Complexity:253

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CNCCC(C1=CC=CC=C1)OC2=CC=CC=C2OC.Cl
Isomeric SMILES:CNCC[C@H](C1=CC=CC=C1)OC2=CC=CC=C2OC.Cl

Technology Process of Nisoxetine hydrochloride, (+)-

There total 3 articles about Nisoxetine hydrochloride, (+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 114446-49-0
-(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

: 74-89-5
methylamine

: 114446-53-6
-(+)-nisoxetine hydrochloride

Guidance literature:: In ethanol; water; at 130 ℃; for 3h;
DOI:10.1021/jo00248a005

Reference yield:

: 100306-34-1,125712-82-5
3-chloro-1-phenylpropanol

: 114446-53-6
-(+)-nisoxetine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature

2: 91 percent / ethanol; H₂O / 3 h / 130 °C

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo00248a005

Reference yield:

: 90-05-1
2-methoxy-phenol

: 114446-53-6
-(+)-nisoxetine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / Ambient temperature

2: 91 percent / ethanol; H₂O / 3 h / 130 °C

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo00248a005