(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

Base Information

Chemical Name:(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate
CAS No.:1196734-96-9
Molecular Formula:C₁₇H₂₄N₂O₇
Molecular Weight:368.387
Hs Code.:

Synonyms:(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

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Technology Process of (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

There total 3 articles about (S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 65160-62-5
N^α-t-butyloxycarbonyl-glycyl-L-tyrosine methyl ester

: 1196734-96-9
(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: N^α-t-butyloxycarbonyl-glycyl-L-tyrosine methyl ester; With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; at 20 ℃;

With sodium dithionite; In water;
DOI:10.1016/j.tetlet.2009.09.034

Reference yield: 60.0%

: 4530-20-5
BOC-glycine

: 1421-65-4
L-dopa methyl ester hydrochloride

: 1196734-96-9
(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile; at 0 ℃; for 5h;
DOI:10.2174/1570178612666150629181357

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 1196734-96-9
(S)-methyl 2-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3,4-dihydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 21 h / 0 - 20 °C

2: triethylamine; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide; acetonitrile / 5 h / 0 °C

With thionyl chloride; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.2174/1570178612666150629181357